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In the Season 4 finale, after a massive bus accident left House without recollection of the accident, he and the team put the pieces of his memory together and discover Wilson’s girlfriend Amber was on the bus with him and was fatally injured. Wilson has to face the shocking realization that House was involved in Amber’s death.

As Season 5 opens, with his friendship with Wilson shattered, House must determine if he’s responsible for Amber’s death and Wilson must decide if House is a destructive force in his life while Cuddy attempts to advance a reconciliation between the two of them.

15 Episodes

  • Dying Changes Everything
    E1
    Dying Changes EverythingIn the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar situation to her own.
  • Not Cancer
    E2
    Not CancerThe team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things about himself that he'd rather not.
  • Adverse Events
    E3
    Adverse EventsA painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.
  • Birthmarks
    E4
    BirthmarksHouse tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
  • Lucky Thirteen
    E5
    Lucky ThirteenThirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas to spy on Wilson.
  • Joy
    E6
    JoyAn ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagnosis before both die. Meanwhile, Cuddy adopts a newborn but when the birth mother displays a rash, she has to make a decision between putting the mother or daughter at risk.
  • The Itch
    E7
    The ItchThe team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relationship issues.
  • Last Resort
    E9
    Last ResortA gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man claims to be sick with a long undiagnosed illness and demands medical attention from the best doctor in the hospital, threatening to kill any hostages necessary along the way.
  • Let Them Eat Cake
    E10
    Let Them Eat CakeThe team takes on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington's Disease drug trials and Thirteen signs on as a subject, Cuddy is forced to move into House's office, and Kutner uses House's name to run an online medical-advice website.
  • Joy to the World
    E11
    Joy to the WorldHouse and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug trials, House gives a patient a gift, the staff wonder who gave House a special gift, and Cuddy gets an unexpected gift.
  • Painless
    E12
    PainlessHouse and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby leaves her with little time to run the hospital.
  • Big Baby
    E13
    Big BabyCuddy takes some time off to be with her baby. She leaves Cameron in charge of daily operations, including supervising House. How will House react when a former employee is now his boss? After learning the truth of Thirteen's drug treatment program, Foreman seeks advice on how to handle the situation.
  • House Divided
    E22
    House DividedHouse's sleep deprivation is beginning to take its toll. He's constantly hallucinating Amber and even needs "her" to come up with ideas to find out what's wrong with a deaf wrestler who during a match started "hearing" loud explosions. Meanwhile, House prepares Chase's bachelor party, complete with strippers and lots of alcohol.
  • Under My Skin
    E23
    Under My SkinWhen all of House's efforts to rid himself of Amber fail, he turns to someone unexpected for assistance. Meanwhile, the team is left to fend for itself as they try to save a ballerina's life and career.
  • Both Sides Now
    E24
    Both Sides NowHouse and his team treat a patient who had his brain split in half, now it seems like one side of his brain is causing some health/behavioral issues. House plays games with Cuddy over the night he detoxed, and those events will cause major changes. Cameron and Chase come to a decision.
  • Hugh LaurieGregory House
  • Lisa EdelsteinLisa Cuddy
  • Robert Sean LeonardJames Wilson
  • Omar EppsEric Foreman
  • Jennifer MorrisonAllison Cameron
  • Jesse SpencerRobert Chase
  • Peter JacobsonChris Taub
  • Olivia WildeThirteen
  • Kal PennLawrence Kutner
  • David HoseltonProducer
  • David FosterProducer
  • Marcy G. KaplanProducer
  • Thomas L. MoranExecutive Producer
  • Russel FriendExecutive Producer
  • Garrett LernerExecutive Producer
  • Katie JacobsExecutive Producer
  • Bryan SingerExecutive Producer
  • Paul AttanasioExecutive Producer
  • David ShoreExecutive Producer
  • Cathy CrandallCostume Design

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  • House M.D.: Season 5
    House M.D.: Season 5Trailer